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STAT4Signal Transducer and Activator of Transcription 4
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There is also evidence showing an epistatic interaction between ERAP and HLA-B51, as well as an association between the STAT4, CCR1, KLRC4, and ERAP1 genes with BS (47).
Gata3 also prevents Th 1 differentiation through its inhibitory effects on IL-12 receptor and STAT4 signaling (Amsen et al.
The STAT4 gene encodes a transcription factor which can be phosphorylated for activation on either tyrosine or serine residues and is expressed in activated blood monocytes, macrophages, and dendritic cells at sites of inflamation in humans.
8] Human genes: PTPN22, protein tyrosine phosphatase, non-receptor type 22 (lymphoid); TRAF1, TNF receptor-associated factor 1; C5, complement component 5); PADI4 (peptidyl arginine deiminase, type IV); STAT4, signal transducer and activator of transcription 4.
10) Asociaciones similares entre SNP de STAT4 y LES han sido reportados en poblaciones suecas, chinas, europeas, africanas, asiaticas e hispanoamericanas.
Two research studies funded by grants from the National Heart, Lung and Blood Institute of the National Institutes of Health (NIH) examined the role of a gene called STAT4 in the development of Type 2 diabetes and other obesity-related cardiovascular diseases.
It has been demonstrated that Th1 differentiation is influenced by STAT1, STAT4 and T-bet and Th2 differentiation is influenced by STAT6, c-maf and GATA-3.
Two new genetic risk factors identified in the past several years are STAT4 and a polymorphism of the intracellular phosphatase gene, PTPN22.
Para su diferenciacion, las celulas Th1 necesitan la presencia de estimulos que favorezcan la produccion de IL-12 por parte de las celulas presentadoras de antigeno (APC), como los organismos intracelulares, lo que lleva a la activacion de vias de senalizacion en las que participan factores de transcripcion como STAT1 (del ingles Signal Transducer and Activator of Transcription), STAT4 y t-bet induciendo la produccion de Interferon gamma (IFN-[gamma]) e inhibiendo el desarrollo de una respuesta de tipo Th2.
The STAT4 SH2 domain binds to IL-12R phosphotyrosines allowing STAT4 to become phosphorylated by the Janus kinases.
Transcription factors involved in the regulation of Th1/Th2 responses (a) Effects on Th2 Th1 Transcription factors phenotype phenotype STAT4 + STAT6 + BCL-6 - T-bet - + GATA-3 + - C-maf + NF-Atc + NF-ATp/NF-AT4 - (a) Th, T-helper; STAT, signal transducer and activator of transcription.
LSF has been shown to reduce interleukin 12 (IL12) signaling and STAT4 activation in target cells and tissues, important pathways linked to inflammation and immune damage to insulin producing cells.