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STAT4Signal Transducer and Activator of Transcription 4
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The STAT4 gene is part of the body's immune response against viruses and regulates tissue inflammation, fibrosis, and anti-viral activity.
Jagodzinski, "Contribution of STAT4 gene single-nucleotide polymorphism to systemic lupus erythematosus in the Polish population," Molecular Biology Reports, vol.
Moreover, LSA pronouncedly inhibited the transcription expression of genes engaged in the IFN-[gamma] associated STATs signaling pathway, including STAT1 and STAT4. STAT-4 expression was significantly reduced in LSA-treated mice.
Lee et al., "STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus," New England Journal of Medicine, vol.
Weaver and Nadler found that IL-12 is able to bind to IL-12 receptors on pancreatic islet [beta] cells and activate proinflammatory cytokines (IL-1[beta], TNF-[alpha], and IFN-[gamma]), resulting in the induction of the apoptosis of islet [beta] cells via the STAT4 signaling pathway [50].
There is also evidence showing an epistatic interaction between ERAP and HLA-B51, as well as an association between the STAT4, CCR1, KLRC4, and ERAP1 genes with BS (47).
stat4 We consider the forms of financial support provided by the state to be adequately set.
Mean ratings for all statements related to DB performance were calculated for each category of the respondents using the Excel PH Stat4. These mean ratings are merely those of the sample.
The recently completed GWAs reported a significant connection between PBC and STAT4, which is also the prominent risk gene in AITD, type 1 diabetes, SLE, RA, SS, and inflammatory bowel disease (IBD) [24, 32, 36, 45].
Additional in silico analysis ofthese polymorphic tandem repeat elements revealed several potential binding sites for transcription factors such as TFII-I, E2F-1, STAT4, and NF-kappa B (Figure 4).
To clarify protein phosphorylation, [beta]-catenin, [beta]-catenin (pS45), Akt (pT308), Akt (pS473), CD140b, Stat1, Stat3, Stat4, Stat5, Stat6, p38 MAPK, Smad2/3, and ERK1/2 were measured using their respective antibodies.