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STAT5Signal Transducer and Activator of Transcription 5
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STAT5 has been implicated in the GH-regulation of IGF-I gene transcription.
BCR-ABL acts through STAT5 to upregulate Sirtuin 1 (SIRT1), a NAD+-dependent protein deacetylase [79, 80].
The glucocorticoid receptor (GR), AP-1 (fos/jun dimer), STAT5 and YY-1 (Ying Yang-1) have been implicated in [beta]-casein gene expression in mice and humans (Mercier and Viloite, 1993; Rosen et al., 1999).
Western blot method was used to evaluate the expression of JAK1, JAK2, STAT1, STAT3, and STAT5 in skin lesions of DH and BP groups (and not perilesional skin) and compared with healthy control group.
The two forms of STAT5 (5a and 5b) are encoded by two different genes, and share 90% homology in their coding sequence (Shuai, 1999; Herrington et al., 2000).
Ligand binding leads to a functional receptor core of these two components, inducing the transphosphorylation of receptor-associated kinases JAK1 and JAK3 and activation of STAT5. Genetic deletion of any member of the IL-7R signaling pathway-- IL-7R[alpha], [gamma]c, JAK1, JAK3, and STAT5--results in severely impaired thymopoiesis and T cell function [8, 9].
Francavilla et al., "PD-L1 negatively regulates [CD4.sup.+] [CD25.sup.+] [Foxp3.sup.+] Tregs by limiting STAT5 phosphorylation in patients chronically infected with HCV" Journal of Clinical Investigation, vol.
The results showed that AhR activation by FICZ or ITE in [CD4.sup.+]T cells cultured in the presence of antiCD3/CD28 and rIL-23 induced STAT3 and STAT5 phosphorylation.
CNS2, corresponding to the TCR-responsive enhancer (enhancer 2), contains a CpG island and binding sites for transcription factors, CREB [29] and STAT5 [30].
IL-7 signalling depends on the engagement of the IL-7R alpha and the common gamma chain on the T cell surface that activates STAT5 and AKT [59].
For Western blot hybridization, the membrane was preincubated with blocking buffer for 2 h and then incubated with primary antibodies against Total IkBa, p-I[kappa]Ba, Total ERK, p-ERK, Total STAT5, pSTAT5, Total STAT3, pSTAT3(727), pSTAT3(705) (all from Cell Signaling, Danvers, ma), and [beta]-actin for 1 h.
Atrapos is focused on developing targeted therapeutics that modulate the body's allergic immune response in specific diseases by inhibiting the intracellular signaling pathways controlled through the transcription factors STAT5 and STAT6.