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STAT6Signal Transducer and Activator of Transcription 6
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PM-43I is also being evaluated in other therapeutic settings where the STAT5 and STAT6 pathways are activated, including as a treatment for chronic sinusitis, idiopathic pulmonary fibrosis (IPF) and atopic dermatitis.
Conventional markers of SFT including diffuse strong positive of CD34,[11] moderately positive of BcL-2 and CD99, and absence of S100, actin, and DOG1.[4],[8] Furthermore, newer immunohistochemistry STAT6 test to detect NAB2-STAT6 fusion gene had been used to differentiate SFT from other mimics and reached significant high sensitivity and specificity.[12],[13] In our case, both histologic characteristics and immunohistochemistry tests showed classic SFT appearance.
The latest research indicates that STAT6 has been gradually applied to pathological examination as a highly sensitive immunohistochemical marker because it shows strong expression in the nuclei but not the cytoplasm of most SFTs.
La inmunohistoquimica reporto inmunoreactividad de las celulas tumorales para BCL2, CD34, CD99, STAT6, CD99 asociado con negatividad para los marcadores CD31, CK y desmina.
Immunohistochemical features of mesenchymal tumors of the prostate SMA Desmin Myogenin CD34 PgR CD117 Pankeratin STUMP -/+ -/+ - + + - - PSS -/+ -/+ - + + - - SMT + + - - - - -/+ IMT + + - - - - -/+ SFT -/+ - - + +/- - - GIST +/- +/- - + - + - RMS + + + - - - - NT - - - - - - - ALK S100 STAT6 STUMP - - - PSS - - - SMT - - - IMT + - - SFT - - + GIST - - - RMS - - - NT - + - STUMP: Stromal tumors of uncertain malign potential, PSS: Prostatic stromal sarcoma, SMT: Smooth muscle tumors, IMT: Infammatory myofbroblastic tumor, SFT: Solitary fbrous tumor, GIST: Gastrointestinal stromal tumor, RMS: Rhabdomyosarcoma, NT: Neural tumors, SMA: Smooth muscle actin, PgR: Progesterone receptor, ALK: Anaplastic lymphoma kinase, STAT6: Signal transduction and activation of transcription 6
Giannini et al., "Regulation of muopioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site," Journal of Biological Chemistry, vol.
Xu et al., "MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)," Biochemical and Biophysical Research Communications, vol.
Insulin resistance resulted from a transition in macrophage polarization from the M2-like activation state, induced by STAT6 activation and PPAR, to a classic M1-like activation state, further driven by NF-[kappa]B, AP1, and other related factors [163-165].
The signature marker of solitary fibrous tumor is the presence of the NAB2-STAT6 fusion that can be reliably detected with a STAT6 antibody.
Sloka S, Silva C, Wang J, Yong VW: Predominance of Th2 polarization by vitamin D through a STAT6 dependent mechanism.
Nowadays, recurrent NAB2-STAT6 gene fusions have been determined in SFT and immunohistochemistry of STAT6 appear like to be useful in the differential diagnosis of other soft tissue tumours.
Hasegawa, the Director of Pathology at Sapporo Medical University, we reached a diagnosis of a solitary fibrous tumor, based on the fact that the tumor tested positive for CD34 and STAT6.