Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD
and the Pittsburgh randomized trial of IPSRT were funded by the National Institute of Mental Health.
Simon NM, Otto MW, Wisniewski SR, et al; for the STEP-BD
Today's article reports on a sub-study of the STEP-BD
The current findings from STEP-BD
examined medications being taken by patients with bipolar disorder I, bipolar disorder II, or bipolar disorder not otherwise specified (NOS) at the rime of study entry.
Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD
population, respectively, but accounted for only 4% each in the STEP-BD
study, she noted.
Many other researchers have mined the rich STEP-BD
data to study the natural history, diagnosis, and treatment of bipolar disorder.
Michael Berk commented that there now is persuasive evidence from STEP-BD
and other studies for using various psychosocial therapies in combination with drug therapy in bipolar disorder.
The prospective course of rapid-cycling bipolar disorder: findings from the STEP-BD
What many colleagues may not know is that STEP-BD
achieved only a 28% positive treatment response.
The principal investigator for one of the largest studies ever conducted in patients with bipolar disorder is encouraging clinicians to look not just at the outcomes of the STEP-BD
trial, but also at the methodology that went into it.