SUAC

AcronymDefinition
SUACShizuoka University of Art and Culture (Japan)
SUACShut Up and Calculate (physics ethos)
SUACSouthampton University Archery Club (UK)
SUACStudents Union Advice Centre (various universities)
SUACSenior University Administrators Course (Canada)
SUACShut Up And Color
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References in periodicals archive ?
[2] Nonstandard abbreviations: NBS, newborn screening; AFP, [alpha]-fetoprotein; TYR1, tyrosinemia type I; SUAC, succinylacetone; NTBC, 2-(2-nitro-4-trifluoromethylbenzoyl)1,3-cyclohexanedione.
In 2008, NSQAP began development of a SUAC QA program to support laboratories that perform NBS tests for tyrosinemia type I.
In this document, we report results from 2 distributions of the SUAC pilot blood spot materials and the first 2 SUAC proficiency testing (PT) challenge panels.
The SUAC (4,6-dioxoheptanoic acid, 99.5% purity) used to prepare stock solutions for enriching whole blood was purchased from Sigma-Aldrich.
We prepared a set of pilot SUAC DBS calibrators by dividing 1 unit of hematocrit-adjusted blood into 7 portions for SUAC enrichment at 0, 1.5, 3.0, 5.0, 10.0, 20.0, and 50.0 j[micro]mol/L and validated the SUAC concentrations by performing duplicate MS/MS analyses (11) of every calibrator in each of 5 runs (Table 1).
(15) requires no substantive new technology or instruments for a laboratory to implement analysis of SUAC, although the laboratory must be set up to deal with hydrazine, a suspected carcinogen.
First, systems must be put in place to be sure there is no mix-up in the sample extracts during recombination of SUAC and amino acid/ acylcarnitine extracts.
The combined result of SUAC and tyrosine appears to be definitive for Tyr-I.
We prepared DBS for SUAC calibration, recovery, stability, and imprecision studies as follows: aliquots of pooled whole blood were spiked with SUAC to achieve final concentrations of 0, 5, 10, 20, 50, and 100 [micro]mol/L, then spotted on filter paper (Whatman ProteinSaver 903) and dried overnight at room temperature.
Sample preparation entails a parallel work-up of eluates from the same DBS that contain either amino acids and acylcarnitines or SUAC. The analytes are subsequently recombined for ESI-MS/MS analysis as outlined in Fig.
Wetransferred the methanol eluates to another round-bottom 96-well plate, leaving the residual filter paper discs for subsequent elution of SUAC for 30 min at 65 [degrees]C by addition of 100 [micro]L acetonitrile/water/formic acid solution (80:20:0.1, vol:vol:vol), which also contains 0.1% hydrazine monohydrate (15 mmol/L) and the internal standard 13C5-SUAC (0.25 [micro]mol/L).
After extraction of SUAC from the leftover dried filter paper spots, the eluates were transferred to another round-bottom 96-well plate and dried under heated (40 [degrees]C) nitrogen for approximately 7 min.