SV40TSimian Virus 40 T Antigen
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(c) RT-PCR showed that U-hiPSCs did not express exogenous markers OCT4, SOX2, KLF4, EBNA-1, miR-302-367, SV40T, and ORIP.
PKKKRKV, which is the minimum NLS of SV40T antigen, has been commonly used in the construction of nonviral genetic vector because it shows high transfection efficiency and low immunogenicity [23,24].
In this line derived from transgenic mice expressing the SV40T antigen (Tag) under control of the tetracycline gene regulatory system, growth arrest can be induced by shutting off Tag expression in the presence of tetracycline.