SWEDDScans Without Evidence of Dopaminergic Deficit
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The SVM classifier using linear kernels was applied to separate SWEDD and PD cases.
We showed that PD and SWEDD patients might be distinguished using connectivity values derived from fiber connections.
Among cortico-cortical connections, bilateral paracentral-posterior cingulate, precentral-posterior cingulate, and posterior cingulate-superior frontal connections showed decreased connectivity in SWEDD compared to PD patients.
There is a lack of comparable studies comparing SWEDD and PD using structural connectivity.
DaT imaging by definition can distinguish between PD and SWEDD [4, 16].
SWEDD patients are heterogeneous, with many different underlying conditions.
[sup][5],[6] However, in clinical practice, dopaminergic functional imaging revealed some patients with mRT to be scans without evidence of dopaminergic deficits (SWEDDs).
The differences in clinical and electrophysiological features between SWEDDs and PD patients were calculated using the unpaired, two-tailed t- test for continuous variables and Chi-square test or Fisher Exact test for categorical variables by SPSS 17.0 (SPSS Inc., Chicago, IL, USA).
There were no significant differences in age, gender, and age at onset of tremor between SWEDDs and PD groups.
A normal symmetrical uptake of [sup]11 C-[sz]-CFT in the bilateral striatum was seen in all five patients (SWEDDs group) [Figure 1] and [Figure 2].
More patients in PD group tended to have difficulties in walking (67.9% in PD group and 20.0% in SWEDDs group, P > 0.05), although the difference was of no statistical significance.