In addition, there are several novel non-tyrosine kinase inhibitors under development that target other serine/threonine
and dual specificity kinases (e.
Significantly down-regulated kinase genes of the adenoma specimens belong to the apoptosis group (MAPK, DNA-PK) and serine/threonine
kinases group (PKC, SGK, NIMA).
The coordination of progression through mitosis is mainly orchestrated by protein phosphorylation insured by several serine/threonine
kinases of which the three main mitotic kinase families are the cyclin-dependent kinase CDKs), the polo-like kinases (Plks), and the Aurora kinases.
A crucial nutrient and energy-sensitive pathway is centred on the Serine/Threonine
kinase mechanistic target of rapamycin (mTOR).
The action of Salubrinal is very specific for the phosphatase complex consisting of the serine/threonine
phosphatase PP1 with its non-enzymatic co-factor GADD34.
South Alabama Medical Science Foundation (Mobile, AL) has patented a composition comprises a glucocorticoid receptor agonist and a compound which decreases levels of active human serine/threonine
protein phosphatase 5 protein in cells.
Chapter 20 Signalling through receptor serine/threonine
There is a wide range of novel molecular targets distributed among these drug candidates, including growth factors, serine/threonine
protein kinases and tumor associated antigens.
Having provided the proof of principle that serine/threonine
phosphatases are drug targets, we aim to investigate the detailed molecular mechanism by which guanabenz selectively inhibits PPP1R15A/GADD34, using a combination of biophysical and structural approaches (Aim 3).
United States Patent 6,162,613, titled "Methods for designing inhibitors of serine/threonine
and tyrosine kinases," describes a method for creating novel, potent chemical classes of inhibitors for a given kinase target.
kinase Pim-1 promotes drug resistance mediated by the ATP-binding cassette multidrug resistance protein breast cancer resistance protein (BCRP, ABCG2) by stabilizing higher-order BCRP multimers
Pim kinases are an exciting class of serine/threonine
protein kinases with a structurally unique ATP binding pocket incorporated in all three isoforms (Pim-1, Pim-2 and Pim-3).