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S/TScience and Technology
S/TSelf-Titled (also seen as ST)
S/TSuch That
S/TSerine/Threonine (DNA)
S/TShort Ton(s)
References in periodicals archive ?
In addition, there are several novel non-tyrosine kinase inhibitors under development that target other serine/threonine and dual specificity kinases (e.
Significantly down-regulated kinase genes of the adenoma specimens belong to the apoptosis group (MAPK, DNA-PK) and serine/threonine kinases group (PKC, SGK, NIMA).
The coordination of progression through mitosis is mainly orchestrated by protein phosphorylation insured by several serine/threonine kinases of which the three main mitotic kinase families are the cyclin-dependent kinase CDKs), the polo-like kinases (Plks), and the Aurora kinases.
A crucial nutrient and energy-sensitive pathway is centred on the Serine/Threonine kinase mechanistic target of rapamycin (mTOR).
The action of Salubrinal is very specific for the phosphatase complex consisting of the serine/threonine phosphatase PP1 with its non-enzymatic co-factor GADD34.
South Alabama Medical Science Foundation (Mobile, AL) has patented a composition comprises a glucocorticoid receptor agonist and a compound which decreases levels of active human serine/threonine protein phosphatase 5 protein in cells.
There is a wide range of novel molecular targets distributed among these drug candidates, including growth factors, serine/threonine protein kinases and tumor associated antigens.
Having provided the proof of principle that serine/threonine phosphatases are drug targets, we aim to investigate the detailed molecular mechanism by which guanabenz selectively inhibits PPP1R15A/GADD34, using a combination of biophysical and structural approaches (Aim 3).
United States Patent 6,162,613, titled "Methods for designing inhibitors of serine/threonine and tyrosine kinases," describes a method for creating novel, potent chemical classes of inhibitors for a given kinase target.
The serine/threonine kinase Pim-1 promotes drug resistance mediated by the ATP-binding cassette multidrug resistance protein breast cancer resistance protein (BCRP, ABCG2) by stabilizing higher-order BCRP multimers
Pim kinases are an exciting class of serine/threonine protein kinases with a structurally unique ATP binding pocket incorporated in all three isoforms (Pim-1, Pim-2 and Pim-3).
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