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SHGBSex Hormone-Binding Globulin
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Testosterone, sex hormone-binding globulin and free androgen index among adult women: chronological and ovarian aging.
Sex hormone-binding globulin is synthesized in target cells.
Rosner, "Solubilization and partial characterization of the sex hormone-binding globulin receptor from human prostate," The Journal of Biological Chemistry, vol.
Second-trimester sex hormone-binding globulin and subsequent development of pre-eclampsia.
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
The authors report no associations with the primary outcomes in women, but an association was found between BPA and concentrations of sex hormone-binding globulin in premenopausal women.
Most T is bound to either sex hormone-binding globulin (SHBG) (60%) or albumin (38%).
The serum free-fraction hormones and sex hormone-binding globulin will identify patterns associated with andropause-related disorders that are specific to decreased production of bioavailable testosterone.
However, measurements of total T or total E levels do not accurately reflect the actual levels of these steroids available to tissues because the fraction bound to sex hormone-binding globulin (SHBG) does not freely pass to target tissues.
On the other hand, fasting insulin concentrations were significantly increased, and sex hormone-binding globulin levels were significantly decreased, compared with controls only, in the PP subgroup.
15) Clinical and experimental evidence suggests that insulin may increase androgen production and effect, through its influence upon steroidogenic enzymes, (23) gonadotrophin-releasing hormone secretion (24) and sex hormone-binding globulin (SHBG) production.