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ssRNASingle-Stranded RNA
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Tan et al., "RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates," Science, vol.
Pathogens for which vaccines are formulated annually, the influenza viruses are enveloped, segmented single-stranded RNA viruses of the Orthomyxoviridae family.
Proventricular dilatation disease (PDD) is a fatal, progressive neurological disorder of psittacine birds, which is caused by a single-stranded RNA virus, the avian bornavirus (ABV).
Idera's gene-silencing oligonucleotides (GSOs) are single-stranded RNA or DNA constructs with two exposed 3'-ends which are complementary to targeted mRNA sequences of therapeutic interest.
Ambros, the Silverman Chair in Natural Sciences and professor of molecular medicine at the UMass Medical School in Worcester, was recognized by the academy for his work in identifying the function of microRNAs, the very short (approximately 22 nucleotide-long) single-stranded RNA molecules that are now understood to play a critical role in gene regulation.
These include hepatitis B, hepatitis C, HIV and human T-cell lymphotrophic virus (a single-stranded RNA retrovirus that can cause leukemia).
By 1994, Japanese researchers had characterized the virus particle, a single-stranded RNA molecule.
New research shows for the first time that certain types of human papillomavirus (HPV), which cause cervical and some other types of cancer, can inhibit the production of a tiny single-stranded RNA called microRNA 34a, or miR-34a.
In addition to targeting specific genes in the body, AVI's antiviral program uses NeuGene antisense compounds to combat disease by targeting single-stranded RNA viruses, including West Nile virus, hepatitis C virus, dengue virus, Ebola virus, and H5N1 avian influenza virus.
Double-stranded RNA activates cellular machinery that chops up single-stranded RNA carrying messages from the particular gene.
Biotin-labeled single-stranded RNA (cRNA) was purified with use of the RNeasy reagent set (Qiagen), eluted in 30 [micro]L of RNase-free [H.sub.2]O, and quantified by ultraviolet spectroscopy.
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