(redirected from Sinonasal Undifferentiated Carcinoma)
SNUCSinonasal Undifferentiated Carcinoma
SNUCStudent Nurses of Ursuline College (Ohio)
References in periodicals archive ?
Sinonasal undifferentiated carcinoma (SNUC) is a rare diagnosis that is associated with a high mortality rate.
Sinonasal undifferentiated carcinoma: Immunohistochemical profile and lack of EBV association Am J Surg Pathol.
The list of differential diagnoses of MM is long and includes sinonasal undifferentiated carcinoma (SNUC), sinonasal neuroendocrine carcinoma, olfactory neuroblastoma, primitive neuroectodermal tumor, rhabdomyosarco ma, and lymphoma.
This is particularly true in poorly differentiated forms that tend to resemble sinonasal undifferentiated carcinoma (SNUC) and other small, round blue cell tumours, such as melanoma, lymphoma, neuroendocrine carcinoma, and rhabdomyosarcoma.
Findings on nasoendoscopic biopsy of the mass were consistent with sinonasal undifferentiated carcinoma (SNUC) (figure 3).
Differentiation of Nuclear Protein in Testis (NUC) Midline Carcinomas, Nasopharyngeal Carcinoma, Small Cell Neuroendocrine Carcinoma, and Sinonasal Undifferentiated Carcinoma NMC SNUC NPC SCN EBV - - + - NUT (C52) + - - - p63 + - or + + - or + Synaptophysin, - - - + chromogranin Abbreviations: EBV, Epstein-Barr virus; NMC, NUT midline carcinoma; NPC, nasopharyngeal carcinoma; SCN, small cell neuroendocrine carcinoma; SNUC, sinonasal undifferentiated carcinoma.
In this way, we were able to distinguish sinonasal NEC from olfactory neuroblastoma and sinonasal undifferentiated carcinoma; all three are neuroectodermal tumors.
(49-60) It is especially important to distinguish these carcinomas from sinonasal undifferentiated carcinoma, which is a highly aggressive, non-EBV-related malignancy with a dismal prognosis.
The differential diagnosis includes other small, round-cell tumors, such as lymphoma, rhabdomyosarcoma, olfactory neuroblastoma, melanoma, sinonasal undifferentiated carcinoma, and pituitary adenoma.
(1,7,11) NUT midline carcinomas are most commonly diagnosed as squamous cell carcinoma, poorly differentiated carcinoma, and sinonasal undifferentiated carcinoma. (4) Despite aggressive treatment with chemotherapy and radiation, the prognosis is poor.
Owing to the "small, round, blue-cell" nature of the neoplasm, the differential diagnosis is quite broad; it includes melanoma, rhabdomyosarcoma, sinonasal undifferentiated carcinoma, lymphoma, Ewing's sarcoma, pituitary adenoma, plasmacytoma, paraganglioma, and primitive neuroectodermal tumor.