Also found in: Medical, Wikipedia.
SIR2Silent Information Regulator 2 (gene)
Copyright 1988-2018, All rights reserved.
References in periodicals archive ?
Tafrov et al., "The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases," Proceedings of the National Academy of Sciences, vol.
Two of the sequences (PvSIR1 and PvSIR2) belong to the SIR2 family of NAD-dependent HDAC proteins, while one of the sequences (PvHD1) belongs to the plant-specific HD2 family.
Guarente, "The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms," Genes & Development, vol.
Frye, "Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (Sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity," Biochemical and Biophysical Research Communications, vol.
infantum protein related to the silent information regulator 2 (SIR2) family has been reported for stimulating the proliferation of activated B lymphocytes, overexpression of major histocompatibility complex- (MHC) II and the co-stimulatory molecules CD40 and CD86 as well as maturation of DCs accompanied by the secretion of IL-12 and TNF-[alpha] are principally governed through TLR2.
Sir2 mediates longevity in the fly through a pathway related to calorie restriction.
Fluorogenic SIRT1 (Sir2) Assay Kit (BPS Bioscience) was used to measure SIRT1.
DEVICES IN ARRAY LINE/MIL SPACING/MIL 805 92 8 8 1206 108 8 8 SO16A 1 8 4 1206 (Non-polarized) 12 8 8 SO16B 1 8 4 1206 (Polarized) 54 8 8 SIR 3 1 16 20 QFP 1 12 12 603 180 8 8 BGA 1 8 8 SIR2 1 16 20 SIR1 1 16 8 TABLE 2.
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.