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References in periodicals archive ?
'Since Cyclerion launched as an independent public company in April, we have made excellent progress advancing our five programs targeting the soluble guanylate cyclase pathway.
Soluble guanylate cyclase stimulators work synergistically with NO on the heme group of sGC, whereas sGC activators work when the heme group is oxidized.
Note the significant amplitude decrease after the soluble guanylate cyclase (sGC) enzyme inhibition.
4A and 4B shows that the vasorelaxant activity of MeOH-Sc was not modified in hypertensive animals in the presence of ODQ (inhibitor of soluble guanylate cyclase).
Similar results were presented by our group on mouse embryonic stem cell-derived cardiomyocytes, where NO had concentration-dependent direct cytoprotective action and soluble guanylate cyclase, PKG, and KATP channels play a role in the downstream pathway of SNAP-induced cytoprotection [15].
Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states.
Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid.
Roberts, both of the Laboratory of Pathology in NIH's National Cancer Institute (NCI), found in mouse and human cell experiments that amyloid-beta, the main component of the plaques that accumulate on brain cells in Alzheimer's, binds to a cell surface receptor called CD36, which causes decreased activity of the enzyme soluble guanylate cyclase to reduce NO signaling.
IW-6463 is an orally administered central nervous system -penetrant soluble guanylate cyclase stimulator that is being developed for the treatment of serious and orphan CNS disorders, the company said.
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