The colonization and time of colonization onset were not associated with different stress ulcer prophylaxis
(p=0.6 and p=0.07, respectively) (Fig.
Keywords: Hospital acquired pneumonia, Proton pump inhibitors, Stress ulcer prophylaxis
PPIs are the most commonly used medications for stress ulcer prophylaxis
in the hospital, despite little evidence to support their use outside the intensive care setting (Heidelbaugh, Metz, & Yang, 2012).
Magnitude and economic impact of inappropriate use of stress ulcer prophylaxis
in non-ICU hospitalized patients.
Despite the presence of guidelines that delineate the limited populations that derive benefit from stress ulcer prophylaxis
(SUP), an estimated 22% to 54% of hospitalized patients receive these "prophylactic" gastroprotective agents, mostly PPIs .
Care processes with the highest correlations (>0.80)--nutrition, weaning off ventilation, deep vein thrombosis prophylaxis, stress ulcer prophylaxis
, BSL recording and management, and bowel activity--may also have good 'face validity' with experts (i.e.
Finally, there is no consensus, in literature, over the discontinuation of stress ulcer prophylaxis
. Some studies suggest the continuation of prophylaxis throughout the duration of the critical illness or intensive care unit stay (27, 28, 29).
The general practice of stress ulcer prophylaxis
in the non-ICU setting has been extrapolated from ICU data without evidence to support need or efficacy, leading to an excessive consumption of antisecretory medications and increased cost.
In our study the indications for PPIs use were stress ulcer prophylaxis
in 32.5% of patients, which was quite different from a recent international study at France22 which showed that 17% of the patients were prescribed PPIs for stress ulcer prophylaxis
, it is because of the fact that most of the patients in our study who were given PPI for stress ulcer prophylaxis
had no appropriate indication for prophylaxis, similarly those who recovered from their critical conditions and did not need any more prophylaxis were continued on PPI, similarly 25% of patients were given stress ulcer prophylaxis
in a study by Hussain et al23.
(2.) Alhazzani W, Alenezi F, Jaeschke RZ, Moayyedi P, Cook DJ.Proton Pump Inhibitors Versus Histamine 2 Receptor Antagonists for Stress Ulcer Prophylaxis
in Critically Ill Patients: A Systematic Review and Meta-Analysis.
The OFT process has been invaluable for stress ulcer prophylaxis
, pressure ulcer prevention, promotion of advance directives, DVT prophylaxis and development of standard protocols for patient care.
Patients in intensive care unit (ICE) settings who are receiving prolonged mechanical ventilation (for >48 hours) have a coagulopathy or multiple organ dysfunction (especially renal failure) should receive stress ulcer prophylaxis
. Current evidence does not support prophylaxis for non-ICU patients (1,2) (strength of recommendation [SOR]: B, based on multiple systematic reviews).