T-LGLT Cell Large Granular Lymphocyte
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In spite of the fact that the majority of T-LGL leukemia cases are of [alpha][beta] type, there are rare cases of [gamma][delta] T-LGL leukemia [2, 13].
Although neutropenia and recurrent bacterial infections are frequent and are considered to be a main cause of morbidity and mortality in patients with T-LGL leukemia, this was not the case with our patient.
It is believed that sustained immune stimulation and a dysregulation of apoptosis underlies T-LGL leukemia pathogenesis, which is why immunosuppressive therapy remains the mainstay of treatment [4].
Few studies reported the use of purine analogs, polyche-motherapy, antithymocyte globulin and other regimens in refractory or relapsed T-LGL leukemia [1,2].
Like HSTL, T-LGL can occur in the setting of immunosuppression and manifests with neutropenia, anemia, and/or thrombocytopenia.