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Zhao et al., "Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste," The Journal of Biological Chemistry, vol.
In this study, we detected the expression of T1R2, T1R3, G[alpha]-gustducin, PLC[beta]2, TRPM5, NLRP3, procaspase-1, and IL-1[beta] in renal tissue of DN model mouse and renal innate cells (mouse GMCs and human proximal tubular cells (HK-2)) under high-glucose stress and then observed the changes of these players using lactisole-blocked STRs, aiming to elucidate the role of STRs in the activation of ROS-NLRP3 inflammasome signaling in the pathogenesis of DN.
The expression of T1R2 and T1R3 in renal tissue was detected by immunohistochemistry (Figure 2(a)), immunofluorescence (Figure 2(b)), and Western blotting (Figure 2(c)).
To determine whether STRs are regulated by glucose in renal innate cells, we first detected T1R2 and T1R3 expression in GMCs (SV-40 MES 13) and human proximal tubular cells (HK-2).
Sclafani, "Impact of T1r3 and Trpm5 on carbohydrate preference and acceptance in C57BL/6 mice," Chemical Senses, vol.
Moreover, mice lacking the T1R3 taste receptor gene developed impaired glucose metabolism, indicating possible involvement of T1R3-mediated glucose sensing mechanisms in the brain .
Modern medicine showed that sweet receptor (T1R2/ T1R3) is also involved in the tissue renewal from stem cells or precursors.
Expression patterns of T1R3 and Ga in the mice testis during various stages of life and throughout the spermatogenic cycle showed that T1R3 and Ga may play important roles in the onset of spermatogenesis, rhythm of spermatogenic cycle, and ageing of the testis .
Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. J Bioi Chem.
(San Diego, CA) a leading company using proprietary technologies to discover and develop novel flavor ingredients for the packaged food and beverage industry, announced today the issuance by the United States Patent and Trademark Office of United States Patent 7,223,551, "T1R3 Receptor Binding Assays For Identification of Taste Modulatory Compounds." The new patent contains broad claims covering binding assays using the human T1R3 taste receptor to screen for compounds that elicit or modulate sweet taste.
In their reports, both groups described the receptor's gene, called T1r3, as the likely basis for the tongue's sweetness sensor.
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- T1-Carrier Error Accumulating Module
- T1-weighted image
- T12 assay
- T2 bacteriophage
- T2 space
- T2 time
- T2 time
- T2 time
- T2 time
- T2 topology
- T2 weighted image
- T2 Weighted Reversed
- T2-separation axiom
- T2-weighted image