T4B

AcronymDefinition
T4BTraining for Business Professionals (Canada)
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Pathologic Staging Categories for Head and Neck Mucosal Melanoma (a,b) pT Primary Tumor pTx Primary tumor cannot be assessed T3 Tumors limited to the epithelium and/or submucosa (mucosal disease) [regardless of thickness or greatest dimension] (c) T4a Moderately advanced disease Tumor invades deep soft tissue, cartilage, bone, or overlying skin T4b Very advanced disease Tumor invades any of the following: brain, dura, skull base, lower cranial nerves (IX, X, XI, XII), masticator space, carotid artery, prevertebral space, or mediastinal structures (a) Reproduced with permission from Union for International Cancer Control (UICC) in Brierley et al (3): Brierley JD, Gospodarowicz MK, Wittekind C, eds.
Casos de neoplasia vesical em estadio T4b como o do caso relatado, sem possibilidades de se submeterem a cirurgia radical curativa, terem resposta completa com regimes quimioterapicos de segunda linha sao considerados raros.
Table 2: TNM staging of upper aerodigestive tract cancers Site T staging Total Tis T1 T2 T3 T4a T4b Glottis 0 15 0 2 2 0 19 Oral cavity 0 2 0 2 3 4 11 Oropharynx 2 0 0 2 2 0 6 Nasopharynx 0 7 0 0 0 0 7 Hypopharynx 0 0 4 0 3 1 8 Salivary gland 0 0 5 0 1 0 6 Maxillary sinus 0 0 0 0 2 1 3 Total 2 24 9 6 13 6 60 Table 3: Presence of lymph node metastasis at the time of presentation Site Level None I I, II II II, III II, V III V Glottis 17 0 0 2 0 0 0 0 Oral cavity 0 7 4 0 0 0 0 0 Oropharynx 0 0 0 1 2 0 3 0 Nasopharynx 0 0 0 2 0 2 0 3 Hypopharynx 0 0 0 2 0 0 6 0 Salivary gland 0 2 0 4 0 0 0 0 Maxillary sinus 0 0 0 0 3 0 0 0 Total 17 9 4 11 5 2 9 3 Site Total Glottis 19 Oral cavity 11 Oropharynx 6 Nasopharynx 7 Hypopharynx 8 Salivary gland 6 Maxillary sinus 3 Total 60 P = 0.0001.
T4B: SI 2 sts to cable needle and hold in back, k2, p2 from cable needle.
After clinical examination and radiological investigations, the tumour was considered either unresectable in advanced T stage (T4b) or technically unresectable when upfront surgery was likely to be associated with positive margins or result in an extremely morbid resection (Figure 1).
Two patients had stage T4b disease with significant radiological and clinical response to treatment.
Segun la profundidad de la invasion tumoral en la pared gastrica, fue mas frecuente hasta la serosa (T4a) con 6 casos (50%), seguidos de la infiltracion neoplasica que sobrepasa la serosa (T4b) con 3 pacientes (25%), y un caso cada uno en los niveles T1b (submucosa), T2 (muscularis mucosa) y T3 (subserosa).
Turbo4bio (T4b) stands for 'Turbo-Reactor for intense biofilm production' and is suitable for the treatment of municipal and low-to-medium-load industrial wastewater, from which it produces a very high-quality effluent with very low sludge production, close to zero.
Contact me by email rlmunday@telus.net; or 333 Luxstone Green SW, Airdrie, Alberta T4B 0A5, Canada.