Consecutive patients admitted with a new-onset acute TAAD and admitted to our hospital from January 2012 to December 2015 were eligible for analysis.
Receiver operating characteristic (ROC) analyses were used to detect the cutoff value of PTX3 levels in prediction of in-hospital mortality in patients with TAAD.
Of the 146 consecutive patients who presented with TAAD admitted to our hospital during the study period, a total of 98 patients fit the inclusion criteria and were included in this study.
3) The in-hospital mortality rates in patients with acute TAAD remained high.
Despite significant advances in the treatment of many cardiac conditions, acute TAAD remains the most catastrophic condition affecting the thoracic aorta, with high in-hospital mortality due to potentially fatal complications such as coronary involvement, even in centers that have extensive expertise and interest in the treatment of high-risk patients.
sup][28] have recently dynamically monitored the systemic inflammatory level and platelet activation with a new acute TAAD canine model.
Therefore, PTX3 provides important prognostic information independently from CRP and it is a more sensitive and immediate inflammatory marker than CRP in patients with TAAD.
Our study identified several clinical variables to be important predictors of death in patients with acute TAAD that are similar to those reported in prior studies.
Despite these limitations, our study provided the evidence for the prognostic significance of PTX3 in TAAD.
In conclusion, this study suggested that high PTX3 levels on admission were independently associated with the in-hospital mortality in patients with TAAD.
