TAGVHDTransfusion-Associated Graft-Versus-Host Disease
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Preterm neonates (<4 months) are at risk for TAGVHD, and the risk increases significantly if the newborn had received prior intrauterine transfusions.
To date, there have not been any confirmed cases of TA-GVHD after transfusion of fresh frozen plasma, cryoprecipitate, any fractioned plasma products, or frozen deglycerolized cells, so these components do not require irradiation for the prevention of TAGVHD. (25,28) There is only a single case in the medical literature where plasma was implicated in TA-GVHD, but that component was fresh plasma.
Theoretically, leukoreduction (also known as leukodepletion or leukofiltration) could remove a sufficient number of white blood cells to limit TAGVHD; however, there have been 23 reported cases of TA-GVHD after transfusion of leukoreduced red blood cells in the literature, (39) indicating leukoreduction alone is not adequate to prevent TA-GVHD.