TAK1


Also found in: Medical.
AcronymDefinition
TAK1TGFbeta Activated Kinase 1
References in periodicals archive ?
NOD1-mediated signaling pathway causes nuclear translocation of NF-[kappa]B subunits through the interaction between receptor interacting protein 2 (RIP2) and TAK1.
Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis.
AMPK[alpha]1 has been demonstrated to play a pivotal role in inducing pro-inflammatory signals through the activation of TAK1 and NF-[kappa]B, (30) but its role in chronic HBV infection remains unclear.
When the protein TAK1 is reduced, satellite stem cells do not vigorously self-renew and many eventually die.
But the TAK1 inhibitor we tested appears to have an effect on diverse WNT pathways involved in the survival of pancreatic CTCs.
MAPK pathways that are activated by MEKK1, TAK1, and ASK1 may link chemical signals to Nrf2 which then leads to the activation of ARE-dependent genes (60).
Science aficionados will love parts of the book such as when Allen find that one of the assassins--a trained commando--is carrying a TAK1 kit to treat radiation exposure despite the fact that he knows of no radiation in the area of the dig.
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK.
94) CagA also associates with TNF receptor associated factor 6 (TRAF6) and TGF-[beta]-activated kinase 1 (TAK1) to induce TAK1 polyubiquitination, which in turn activates TAK1.
Both proteins leave the receptor complex and interact with TGF-[beta]-activated kinase 1 (TAK1) and two TAK1 binding proteins TAB1 and TAB2.
The supernatant proteins (30 [micro]g) were separated by 10% SDS-polyacrylamide gel electrophoresis, transferred to polyvinylidenedifluoride membranes, and then hybridized overnight, at 4[degrees]C with 1:1000 diluted antibody of COX-2, iNOS, p65, p-p65, TAK1, p-TAK1, p38, p-p38, JNK, p-JNK, ERK, p-ERK, occludin, claudin-1, ZO-1 or [beta]-actin, then incubated with 1:2000 diluted anti-rabbit or anti-mouse IgG secondary antibody for 1 h at room temperature, and washed 3 times with PBS containing 0.
Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1.