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TAP2Transporter Associated with Antigen Processing
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We found TAP2 to have had a greater impact on farmers largely due to its flexibility and adjustments made to the programme design based on lessons learned from TAP1.
The highest and lowest mean Staphylococcus aureus counts were 475 Cfu/ml and 75 Cfu/ml in Tap5 and Tap2, respectively.
In the cytosolic pathway, degraded intracellular proteins are transported to the rough endoplasmic reticulum (RER) via TAP, a heterodimer consisting of TAP1 and TAP2. These peptides are further trimmed by aminopeptidases ERAP to enable optimal peptide loading onto MHC class I molecules.
The 15 SNPs include rs116076690, rs2071543 in PSMB8 , rs17587 in PSMB9 , rs1135216 in TAP1 , rs2228391, rs2228396, rs241447, rs241448, and rs4148876 in TAP2 , respectively [Figure 1]a.
Our study showed significant association between CTLA-4, IL-18, VDR, TAP2, IL-12, and CD4 genes and T1DM.
tap1 <OE tepen; ?<OF taper, strike, or of imitative origin; unrelated to tap2, faucet
In a study evaluating human melanoma tissues levels of TAP1 and TAP2 were greatly reduced in metastatic lesions and the reduction in TAP levels in primary lesions correlated with lesion thickness, disease stage, faster disease progression and lower survival rates.
La proteina asociada a transporte en el procesamiento de antigenos (TAP) es una proteina compuesta de dos polipeptidos, TAP1 y TAP2. El gen de TAP2 esta asociada con lepra tuberculoide.
One of the first studies reporting candidate gene experimental design was performed with the transporter associated antigen processing molecule 2 (TAP2), which is located on chromosome 6p21, and plays an important role in peptide translocation inside the cell and their binding to major histocompatibility complex (MHC) molecules.
RT-PCR was performed with the primers for [[beta].sub.3]m, LMP2, LMP7, TAP1, TAP2, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a loading control (Table 1).