As shown in Figure 2, HbA1c (%) levels correlated negatively with Z-scores for TBBMD, TBBMC, and LBM (r = -0.27, -0.30, and -0.32; p < 0.05, respectively) as well as Z-scores for absolute TBBMC (r = -0.28, p = 0.038) and LBM (r = -0.27, p = 0.040) (data not shown).
After adjusting for disease duration, age, sex, pubertal stage, insulin dose, height, weight, and physical activity level, significantly lower Z-scores were noted in the HbA1c [greater than or equal to]8% subgroup for TBBMD and TBBMC, as well as for the TBBMC/LBM ratio (Figure 3).
In conclusion, our results showed that adolescent patients with T1DM had lower physiological values of TBBMD, TBBMC, and S24BMD and worse relative bone strength index (TBBMC/LBM ratio), coinciding with higher FM and FM/LBM ratio values compared to age- and sex-adjusted generally healthy counterparts.
Abbreviations TBBMD: Total body bone mineral density TBBMC: Total body bone mineral content LBM: Lean body mass FM: Fat mass S24BMD: Bone mineral density, lumbar spine L2-L4 S24BMC: Bone mineral content, lumbar spine L2-L4 S24BMC/LBM: Bone mineral content, lumbar spine L2-L4/ lean body mass ratio TBBMC/LBM: Total body bone mineral content/lean body mass ratio FM/LBM: Fat mass/lean body mass ratio HbA1c: Glycated haemoglobin A1c.
Multiple regression analysis in 30 osteoporotic women of (a) the TBBMC corrected for body weight (TBBMC/W) as dependent variable with the biochemical markers of nutrition transferrin (TF), prealbumin (PreAlb), retinol-binding protein (RBP) and fibronectin (FN) as independent variables; and of (b) the TBBMC as dependent variable with plasma (P Zinc) levels and urinary zinc (U Zinc) excretion as independent variables
(b) Dependent variable: TBBMC ([R.sup.2] 2 = 0.523; F test= 5.882; p = 0.0022)
TBBMC correlated with urinary zinc concentration in the women with postmenopausal osteoporosis (simple linear regression: r = 0.