TBBMDTotal-Body Bone Mineral Density
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After adjusting for disease duration, age, sex, pubertal stage, insulin dose, height, weight, and physical activity level, significantly lower Z-scores were noted in the HbA1c [greater than or equal to]8% subgroup for TBBMD and TBBMC, as well as for the TBBMC/LBM ratio (Figure 3).
In conclusion, our results showed that adolescent patients with T1DM had lower physiological values of TBBMD, TBBMC, and S24BMD and worse relative bone strength index (TBBMC/LBM ratio), coinciding with higher FM and FM/LBM ratio values compared to age- and sex-adjusted generally healthy counterparts.
Abbreviations TBBMD: Total body bone mineral density TBBMC: Total body bone mineral content LBM: Lean body mass FM: Fat mass S24BMD: Bone mineral density, lumbar spine L2-L4 S24BMC: Bone mineral content, lumbar spine L2-L4 S24BMC/LBM: Bone mineral content, lumbar spine L2-L4/ lean body mass ratio TBBMC/LBM: Total body bone mineral content/lean body mass ratio FM/LBM: Fat mass/lean body mass ratio HbA1c: Glycated haemoglobin A1c.