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As their name suggests, TBVs target the parasite stages that develop within the mosquito vector, and as a result, prevent the subsequent cascade of events that leads to infection of human hosts.
For a molecule to be an effective TBV candidate, certain basic principles must be followed.
The obtained results proved its usefulness in further application of this part of genome for designing a regional TBV.
Although a number of parasite proteins have been identified as potential antigens for TBV (75,76), of particular interest are P.
The efficacy of the TBV will be dependent upon the proportion of gametocyte carriers immunized in a local transmission area.
(74.) http://www.who.int/tdr/publications/publications/pdf/ malaria tbv.pdf accessed on 12/12/07.
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