Sampling at these and several other mills showed TCDD and TCDF accounted for 93 to 99 percent of the dioxin/furan toxicity in bleached pulps and wastes, according to Gary A.
His analyses of paper towels, paper plates and facial tissue identifed both TCDF and TCDD.
When Ryan analyzed his cardboard milk cartons, he found TCDD and TCDF
TCDF binds the aryl hydrocarbon receptor (AHR), which activates a variety of biological responses.
For five days, Patterson's team fed food pellets spiked with 24 pg/kg TCDF to adult male mice that either carried or lacked the AhR gene.
Now they're feeding mice lower chronic doses of TCDF, and according to Patterson, preliminary data are showing similar changes as those seen at higher TCDF doses.
Patterson's results "show significant changes in the gut microbiome profile after TCDF administration, and they raise very interesting and important questions.
1]H nuclear magnetic resonance (NMR)-based metabolomics to investigate the alteration of gut microbiota and the host metabolome in mice treated with TCDF through the diet.
After acclimatization for 1 week to normal flora in our facility, mice were randomly divided into two groups of six and trained to eat transgenic dough pills (Bio-Serve) that contained no TCDF (Cambridge Isotope Laboratories Inc.
Effects of dietary TCDF on liver enzymes and morphology.
50] (M) REP (a) ligand compound effect (%) TCDF
- 100 2.
9 Abbreviations: HpCDD, heptachlorodibenzodioxin; HpCDF, heptachlorodibenzofuran; OCDD, octachlorodibenzodioxin; OCDF, octachlorodibenzofuran; TCDF