ILCs develop from hematopoietic precursors and their development is partially or wholly dependent on the common [gamma]-chain, Notch, the transcription factor inhibitor of DNA binding-2 (Id2), IL7, a cytokine involved in hematopoietic cell development and proliferation [3-6], and other transcription factors such as T-bet for ILC1, ROR[alpha] and Gata-3 for ILC2, and
TCF1 and Gata-3 for ILC3 (Figure 1).