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For example, in the freezing stage, a rule of thumb is that the product is cooled well below the critical temperature (Tcrit) of the formulation to ensure it is completely frozen.
Primary drying is conducted at a lower pressure and slightly higher temperature compared to the freezing stage, but still below Tcrit to promote sublimation, while the secondary drying is conducted at the minimal pressure and a higher temperature.
The paired t-test was calculated for n-1 = 5 degrees of freedom, texp (0.146) was less than the tcrit (2.57) at 95% confidence interval (P = 0.05).
La edad critica tcrit, corresponde a la edad donde esta variacion es igual a cero y analiticamente conduce a la expresion derivada del modelo de rendimiento por recluta de Beverton y Holt:
A preselected threshold temperature TCrit determined whether this contribution was rainfall and immediate.
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