TDGF1Teratocarcinoma-Derived Growth Factor 1
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At p4, all five cell lines exhibited enhanced expression of nine genes (ZFP42, TDGF1, SFRP2, PODXL, NR6A1, CD9, DNMT3B, IFITM1, and LIN28), which are all related to stemness, and reduced expression of four genes (TAT, PAX4, IAPP, and DDX4), which are related to differentiation (Figure 1(c)).
NODAL, LEFTB, EBAF, TDGF1, UTF1, and LIN28 showed a variation of more than 50% for both p4 and p9.
NODAL lacks intrinsic affinity for ACVR2A/2B and ALK4 and requires CRIPTO-1, also known as teratocarcinoma-derived growth factor-1 (TDGF1), which belongs to the epidermal growth factor-Cripto-FRL1-Cryptic (EGF-CFC) family, and it has a pivotal role during embryogenesis and tumorigenesis [27].