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The standard cytology test needs a doctor to look down a microscope to read the results, but the TERT test is read by a machine, which is simpler, more accurate and available to use straightaway," says Professor Alain Ruffion, a researcher based at the University Hospital of Lyon's Oncology Institute.
Additional factors are needed for full activity of the telomerase complex besides TERT and TERC.
The report [sup] from Mayo Clinic and UCSF defined a priori groups that were based on the presence or absence of TERT promoter mutations, IDH mutations, and 1p/19q codeletion and found consistent associations between the molecular groups and age at diagnosis, survival, patterns of acquired alterations, and germline variants across the three data sets.
The researchers showed that a key protein called p50 interacts with several components of telomerase, including TERT, Teb1 and p75, and this network of interactions has important implications for telomerase's function.
Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells"; The FASEB Journal, 2015; DOI: 10.
11 Certain studies involving mouse models for two stage tumorigensis showed that TERT over expression promoted papilloma formation.
While assessing alternative splice variants of TERT expression, the scientists identified full-length TERT and the alpha- and beta-deletion forms, with the full-length form being associated with short survival (P=.
TERC and TERT mutations (5%-10% each of all cases) are found in autosomal dominant and recessive DC and show disease anticipation, such that successive generations not only inherit the genetic lesion but also have shorter telomeres, which may produce an earlier onset of clinical manifestations (8).
Structure of the Tribolium castaneum telomerase catalytic subunit TERT.
Manipulating TERT could open up new avenues for developing therapies, suggest the researchers, led by Dr Steven Artandi, from Stanford University in California.
They taught dendritic cells to make a part of the telomerase protein called TERT and display it on their surfaces.
Moreover, the in vitro malignant transformation of normal human cells was achieved by reconstitution of telomerase activity by induction of TERT gene expression in combination with other oncogenes (5,10).
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- Tersk Horse
- Terskei Alatau
- Terskov, Ivan
- Terskov, Ivan Aleksandrovich
- Terson forceps
- Terson glands
- Terson speculum
- Terson syndrome
- Terson's syndrome
- Terson, Albert
- Tert Butylbicyclo Ortho Benzoate
- Tert-Amyl Methyl Ether
- Tert-Butyl Catechol
- tert-butyl chloroacetate
- Tert-Butyl Glycidyl Ether
- Tert-Butyl Hydroperoxide
- Tert-butyl methyl ether
- Tert-Butyl Quinone
- Tert-Butyl-2-Benzothiazyl Sulfenimide
- Tert-Butylquinone Oxide
- Terterian, Arsen
- Terterian, Arsen Arutiunovich
- Tertian (unit)
- Tertian (unit)