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Conclusion: Using next-generation sequencing technology in familial IPF patients, we identified the heterozygous rare variant in TERT gene, and strengthened the importance of genetic variants in telomere-related pathogenesis in Chinese IPF patients.
Recently, McEvoy and colleagues reported a ddPCR assay for TERT promoter mutations by use of Q solution and locked nucleic acids (3).
EPCs were first treated with Ang II or TERT, following which the total cellular proteins were extracted using RIPA lysis buffer (ELPIS BIOTECH, Korea).
We further found that Par-4 can interact with TERT in a yeast two-hybrid system, and other studies have indicated that the interaction between Par-4 and TERT may inhibit TERT in the cytoplasm of nasopharyngeal carcinoma cells, leading to apoptosis.
"The standard cytology test needs a doctor to look down a microscope to read the results, but the TERT test is read by a machine, which is simpler, more accurate and available to use straightaway," says Professor Alain Ruffion, a researcher based at the University Hospital of Lyon's Oncology Institute.
Additional factors are needed for full activity of the telomerase complex besides TERT and TERC.
TERT (5p15.33) encodes a telomerase, a ribonucleoprotein that maintains telomere ends by addition of telomere repeat TTAGGG.
The researchers showed that a key protein called p50 interacts with several components of telomerase, including TERT, Teb1 and p75, and this network of interactions has important implications for telomerase's function.
Ramunas et al.; "Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells"; The FASEB Journal, 2015; DOI: 10.1096/fj.
Normal keratinocytes was transfected with TERT gene and after treatments with TPA were assayed again for cloning efficiency.
The research team utilised quantitative real-time polymerase chain reaction to evaluate the expression of telomerase reverse transcriptase (TERT), splice forms and telomere length, while the activity of telomeres was assessed by enzyme-linked immunosorbent assay (ELISA).
Tender documents to be obtained from the Authority's premises at Tert Nag Hammadi St., Sohag West.
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- Tersk Horse
- Terskei Alatau
- Terskov, Ivan
- Terskov, Ivan Aleksandrovich
- Terson forceps
- Terson glands
- Terson speculum
- Terson syndrome
- Terson's syndrome
- Terson, Albert
- Tert Butylbicyclo Ortho Benzoate
- Tert-Amyl Methyl Ether
- Tert-Butyl Catechol
- tert-butyl chloroacetate
- Tert-Butyl Glycidyl Ether
- Tert-Butyl Hydroperoxide
- Tert-butyl methyl ether
- Tert-Butyl Quinone
- Tert-Butyl-2-Benzothiazyl Sulfenimide
- Tert-Butylquinone Oxide
- Terterian, Arsen
- Terterian, Arsen Arutiunovich
- Tertian (unit)
- Tertian (unit)
- tertian fever