TGF-bTransforming Growth Factor Type Beta
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References in periodicals archive ?
Shibanuma, "Transcriptional induction of MMP-10 by TGF-B, mediated by activation of MEF2A and downregulation of class IIa HDACs," Oncogene, vol.
Activation of the bone-derived latent TGF-b complex by isolated osteoblasts.
Osteoblasts synthesize and respond to TGF-b in vitro.
But when they blocked TGF-b with specific antibodies, it neutralized these drug effects and prevented the spread of tumors.
Recently, numerous studies have found that TGF-[beta] signal is activated in the early phase of AP, and inhibition of TGF-[beta] signal decreases pathological injury to pancreas (8-13), suggesting TGF-b signal could be a target for therapy of AP.
Sosa-Garrocho Marcela and Universidad Nacional Autonoma de Mexico, "El factor de creciemiento transformante beta(TGF-b): funciones y vias de transduccion," Boletin Fisiologia Celular, UNAM, vol.
For the recent experiments, the NLGs contained two components: an inhibitor drug that counters a particularly potent cancer defense called transforming growth factor-B (TGF-B), and interleukin-2 (IL-2), a protein that rallies immune systems to respond to localized threats.
The 'moat' is the cancer's defense system, which includes TGF-B.