TGHDTotal Growth Hormone Deficiency
Copyright 1988-2018, All rights reserved.
References in periodicals archive ?
Our behavioral study demonstrated that tgHD rats show gait abnormalities in the early symptomatic phase of the disease.
Among the static parameters of gait, base of support, and stride length, only the latter turned out to be significantly increased in the hind paws of the tgHD rats.
Base of support is by definition the average width between the front and hind paws and is frequently increased to compensate for an instable gait [26] and to increase balance [27], which we expect to occur at later stages of the disease in tgHD rats.
As we hypothesized, the dynamic parameters seem to be more affected at this age than the static parameters in tgHD rats.
Through gait analysis, it was shown that tgHD rats in pre-manifestation phase have a hyperkinetic profile, characterized by increased swing speed, decreased paw contact, and increased speed [21].
Moreover, in favor of this reasoning is the fact that gait abnormalities were detected at 2 months of age in tgHD [21] when choreiform movements are not yet present.
Our previous works have shown that (i) the tgHD rats exert a hyperdopaminergic status, expressed in an increased number of dopaminergic cells in the brainstem, accompanied by an enhanced dopamine expression in the striatum [28, 29]; (ii) the choreiform movements can be reduced by the administration of tetrabenazine, a reversible inhibitor of the vesicular monoamine transporter [9], similar to clinical practice.