TGRMTask Group for the Reference Model
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What then makes a transcultural global responsible manager (TGRM) different?
Mice expressing human PrP (tgRM and tg66) were generated by using a transgene, cosSHa.HumPrP, which was created by ligating the human PrP open reading frame into the cosSHa.Tet vector (21).
The lack of transmission to tgDeerPrP, tg66, or tgRM mice from the 3 squirrel monkeys with detectable CWD PrPres indicated that either the infectivity levels were low in these squirrel monkeys or that the original cervid species tropism was altered by the passage in squirrel monkeys.