TH-IRTyrosine Hydroxylase-Immunoreactive
TH-IRTime-Hopping Impulse Radio
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Stereological TH-ir nigral cell counts of mice treated with vehicle + MPTP or LSN at 3, 10, and 30 mg/kg + MPTP showed a significant reduction in TH-ir neurons compared to vehicle + PBS.
The preservation of nigral TH-ir and Nissl positive cell counts confirms that treatment with LSN enhanced the survival of DA nigral neurons, instead of inducing upregulation of the dopaminergic phenotype [35].
Double-label immunofluorescence demonstrated [alpha]-syn aggregates in TH-IR neurons in the SN of LPS-injected Tg mice (Figure 3B).