To our knowledge, there are no standard normative data for urine levels of MMP2, MMP9, TIMP1
, TIMP2, TGF-p1 in children by age group.
Figures 5(a)-5(c) show that acetaldehyde significantly increased the expressions of several profibrogenic markers: Col1A1, TIMP1
, and TIMP2.
These results offer further evidence that Egr1 can promote kidney fibrosis in addition to binding to the promoters of COL1A1, COMP, periostin, MMP2, TIMP1
, and OPN.
ADIPOQ = adiponectin, C1Q and collagen domain containing; IRS2 = insulin receptor substrate 2; ACSL1 = acyl-CoA synthetase long chain family member 1; PLIN = lipid storage droplet 2-like; CD36 = CD36 molecule; PNPLA3 = patatin-like phospholipase domain containing 3; SCD = stearoyl-CoA desaturase; BDKRB2 = bradykinin receptor B2; ADORA3 = adenosine A3 receptor; SOX9 = sex determining region Y-box 9; TXN = thioredoxin; CDKN2C = cyclin-dependent kinase inhibitor 2C; GSTM3 = glutathione S-transferase mu 3; PTH1R = parathyroid hormone 1 receptor; CKB = creatine kinase B; AOC1 = amine oxidase, copper containing 1; AOC3 = amine oxidase, copper containing 3; TIMP1
= TIMP metallopeptidase inhibitor 1; PTN = pleiotrophin.
Furthermore, the mRNA expression levels of Acta2, Coll1a1, TIMP1
, and Myh11, which are classical markers for HSC activation, were significantly reduced in EXE-treated rHSCs (Figure 4(d)).
The increased level of secreted TIMP1
and VEGFA with increasing duration of post-exposure in the basolateral media of the exposed tissues (i.e., 3R4F (0.15) and THS2.2 aerosol (at all concentration tested) further substantiates the notion of activation of a cellular repair response.
fPSA MMP7 MMP13 Mean Ranks Case:16.05 Case:23.55 Case:25.71 Control:30.88 Control:13.38 Control:8.33 Mann-Whitney U 43.50 82.50 22.0 Significance <0.001 0.010 <0.001 (p value) TIMP1
TIMP2 Mean Ranks Case:21.71 Case:17.30 Control: 17.67 Control:27.96 Mann-Whitney U 134.0 78.50 Significance 0.328 0.007 (p value) Table 2.
and A2M govern the degradation of the extracellular matrix [15,16].
Herrick et al., "Association of markers for TGF[beta]3, TGF[beta]2 and TIMP1
with systemic sclerosis," Rheumatology, vol.
Cui, "Effects of CaD on glomerulus TIMP1
and collagen IV of diabetic rats," Journal Huazhong University of Science Tecnology and Medical Sciences, vol.
Expression of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP1
) by colorectal cancer cells and adjacent stroma cells-associations with histopathology and patients outcome.
For instance, TIMP1
strongly inhibits many MMPs excepting membranar type, including MMP14,-15,-16,-19 and -24 [30, 32].