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TLCOTransfer Factor of the Lung for Carbon Monoxide
TLCOLow Carbon Monoxide Transfer Factor
TLCOTechnical Requirements Manual Limiting Condition for Operation
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TLCO was significantly lower in normal-weight patients as compared to pre-obese and obese patients (p<0.001, Table 1), but there was no significant diference between the groups in terms of 6MWD (p=0.761, Table 1).
Similar to the literature (18), we found that the TLCO value was significantly higher in the obese patients.
Severity of airflow obstruction (4) Severity FEV1 (%) Stage post-bronchodilator Predicted Comments 1 Mild [greater than Only diagnosed in the or equal to] presence of symptoms 80% 2 Moderate 50- 79% Managed within the community 3 Severe 30-49% TLCO usually Low Hospitalization may be needed only with exacerbations 4 Very Severe <30% Or FEV1 <50% with respiratory failure Table 2.
We hypothesised that in apparently healthy heavy smokers, maximal exercise capacity could be related to the resting TLCO values.
Carbon monoxide transfer capacity (TLCO) was measured by the single breath method using a mixture of carbon monoxide and methane.
In smokers, mean values of [FEV.sub.1] (% of pred), [FEV.sub.1]/SVC (%), TLC (% of pred) and TLCO (% of pred) were 103% [+ or -] 10, 78% [+ or -] 6, 105% [+ or -] 9 and 79% [+ or -] 10, respectively.
In smokers, but not in healthy controls TLCO (%) correlated with workload (r = 0.637, p < 0.05), peak [VO.sub.2] (r = 0.546, p < 0.05) and oxygen pulse at peak exercise (r = 0.663, p < 0.01) (Figure 2).
In this study, we showed that smokers, even without cardiopulmonary disorders, had lower resting TLCO values than healthy controls.
The increased carboxyhaemoglobin seems to contribute to the reversible decrease in TLCO. The effect of carboxyhaemoglobin in reducing TLCO is greater than it would be predicted by the back CO capillary pressure effect alone.
In the present study, we found that in smokers, TLCO values were directly related to and can predict maximal exercise capacity in terms of workload, oxygen uptake and oxygen pulse, and, accordingly, we provided the prediction equations.
Now as a wholly-owned Cal-Bay subsidiary, COBS is lauding Maki's TLCO Software as a key tool in a making a "quantum leap" in their expansion plans in the online homebuilding and construction arena.