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Halickova et al., "Studies on the regulation of transient lower esophageal sphincter relaxations (TLESRs) by acid in the esophagus and stomach," Diseases of the Esophagus, vol.
As an alternate approach to the treatment of GERD, baclofen, a GABAb agonist, reduces the frequency of reflux events and inhibits TLESR .
The Rate of TLESR in the PP Population Who Were Given Either Baclofen Or Placebo for the Treatment of GERD.
Baclofen treatment was associated with a significant reduction in the number of GER episodes, the acid reflux time, and the incidence of TLESR. Our meta-analysis also demonstrated that there is no statistically significant difference in the occurrence of the overall adverse events between baclofen- and placebo-treated subjects and that the drug was well tolerated.
All trials included in the meta-analysis provided categorical information about the types of GERD-related symptoms (the incidence of TLESR, GER, gastric emptying, pharyngeal swallowing, and lower esophageal sphincter pressure and the acid reflux time).
Many studies have shown that baclofen can reduce GER episodes [27, 28] and decrease the acid reflux time and the incidence of TLESR [29, 30] in normal individuals and patients with GERD.
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