Talend (NASDAQ: TLND
) delivers a single platform for data integration across public, private, and hybrid cloud, as well as on-premises environments, and enables greater collaboration between IT and business teams.
Laryngeal cancer with subglottic extension (LCSE) and metastasis-free cervical lymph nodes (pN0) observed after total laryngectomy and neck dissection (TLND) presents a treatment dilemma that demands consideration of the potential danger of undertreatment and the unnecessary morbidity of overtreatment.
Analysis of our patients who did not receive postoperative radiotherapy revealed that they had a greater than 20% risk of neoplastic recurrence in the neck when the central compartment lymph nodes were not removed (because the LCSE was not appreciated prior to definitive surgery) and thyroid gland lobectomy was not performed with TLND. Also, we recognize that (1) the presence of negative nodes does not reliably rule out recurrent disease because micrometastases do exist and (2) although the classic treatment of head and neck cancer addresses the primary tumor and the lymphatic drainage, elective neck dissection can deprive the host of an active immunologic barrier.
Fewer than 40 cases of LCSE following TLND have been reported in the literature.
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