Also found in: Wikipedia.
TLR2Toll-like receptor 2
Copyright 1988-2018, All rights reserved.
References in periodicals archive ?
In this study, it was analyzed whether the TLR4 Asp299Gly and Thr399Ile and TLR2 intron 2 gene polymorphisms caused a tendency for the development of acute biliary pancreatitis and whether there was a difference between patients in terms of these gene polymorphisms according to the imaging findings and recurrent disease.
(3,13) It activates TLR2 on monocytes, leading to the release of proinflammatory cytokines IL-12 and IL-8.
###TLR4 on ECs.152 TLR2 and TLR4 monitor the extracellular environment and recognize PAMP of P.
Properties of representative chemically identified adjuvants Category Adjuvant Receptor Adaptor Lipid MPL TLR4 MyD88/TICAM-1 Lipopeptide TLR2 (+TLR1 or TLR6) MyD88 Oil, squalane Undefined Undefined Protein Flagellin TLR5 MyD88 Cholera toxin B GM1 receptor G proteins Versican TLR2 MyD88 Nucleic acid Virus dsRNA TLR3, MDA5 TICAM-1 /MAVS Poly I:C TLR3, MDA5 TICAM-1 /MAVS CpG DNA TLR9 MyD88 STING ligand cGAS etc.
As shown in Table 3, compared with the sham intervention, the true purification intervention was associated with significantly lower expression of IL1 mRNA and protein and significantly higher expression of the single miRNA predicted for IL-1 (miR-21-5p); with significantly lower TNF mRNA (but not TNF-[alpha] protein) and significantly higher expression of the miRNA predicted for this cytokine (miR-187-3p); with significantly lower TLR2 mRNA (but not TLR-2 protein), and significantly higher expression of one of the two miRNAs predicted for this cytokine (miR-146a-5p); and with significantly lower EDN1 mRNA and ET-1 protein and significantly higher expression of both miRNAs predicted for this cytokine (miR-1-3p and miR-199a-5p).
Elevated CD14 (Cluster of Differentiation 14) and Toll-Like Receptor (TLR) 4 Signaling Deteriorate Periapical Inflammation in TLR2 Deficient Mice.
HEK293T cells, a human embryonic kidney cell line obtained from ATCC, USA, were used to stably express human TLR2, as described previously (under submission [74]).
In order to determine the effect of inflammatory reactions in the pathogenesis of miscarriage, genotyping of promoter sites was carried out using the following polymorphic markers: G753A for TLR2; C399T for TLR4; G2848A for TLR9; C509T for TGF-[beta]1; PROGINS for PGR; G174C for IL-6; C781Tfor IL-8; C592A for IL-10; and G308A for TNF[alpha].
Correa-Costa et al., "TLR2, TLR4 and the MYD88 signaling pathway are crucial for neutrophil migration in acute kidney injury induced by sepsis," PLoS One, vol.
Moreover, the relative levels of the RAGE mRNA were increased after 48 h of PM2.5 treatment, but significant differences in the levels of TLR2 and TLR4 were not detected, although a slight increase in expression was observed (Figure 2(c)).
TLR2, the other receptor related to initial immunization, was significantly upregulated.
The mechanism of action was not selective, since the disruption of TLR dimerization occurred on both TLR4 and TLR2, by covalent binding.