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In opposition to TLR4, which forms homodimer, the transmission of signals from TLR2 initiates after its homodimerization as well as its heterodimerization with either TLR1 or TLR6, and possibly TLR10, providing more capability to recognize more ligands molecules and induce different responses (10,12).
From the results of RNA-Seq, we also found that the expression of TLR6 and NF-[kappa]B was significantly upregulated.
Puente et al., "Increased expression profile and functionality of TLR6 in peripheral blood mononuclear cells and hepatocytes of morbidly obese patients with non-alcoholic fatty liver disease," International Journal of Molecular Sciences, vol.
RT-PCR was performed to detect the mRNA levels of TLR2, TLR3, TLR6, CD36, and SYK at 6 hours after LPS stimulation.
Additionally, some toll like receptors including TLR1, TLR2, TLR4, TLR5 and TLR6 recognize bacteria (Iwasaki and Medzhitov, 2004).
Some of the genes under the strongest pressure are Toll-like receptor genes TLR1, TLR6 and TLR10.
(1) Depending on their cellular localization or respective PAMPs they identify, TLRs can be divided into two sub groups such as transmembrane (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR11) and intracellular (TLR3, TLR7, TLR8, and TLR9).
Interleukin-1, diacyllipopeptide and lipopolysaccharide are recognized by interleukin-1 receptor (IL- 1 R), a complex of TLR2 and TLR6, and TLR4, respectively.
La activacion de macrofagos esta mediada a traves de la proteina adaptadora MyD88 (factor de diferenciacion mieloide 88), pero de forma independiente del reconocimiento por TLR4 o TLR6 (20,21).
TLR1, TLR2, TLR4, TLR5, and TLR6 were expressed on phagocyte cell surfaces and TLR3, TLR7, TLR8, and TLR9 localized within intracellular vesicles.
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