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Forty rats were subjected to 90 minutes of transient middle cerebral artery occlusion (tMCAO) and then treated with PBS or DAPT at 3 days after ischemia.
[27,28,32] model was followed as a part of the research facility [27,28, 33,34] for the surgical ligation of tMCAo. This technique involved isolation of the left common carotid artery (LCCA) using loose ligation with silk 4-0.
SCM-198 was surprisingly found to be effective in permanent MCAO stroke models via modulating mitochondrial functions , which prompted us to further explore its possible therapeutic potential in more dangerous tMCAO models.
Animal Surgery for tMCAO. The mouse tMACO model was established by following the surgical procedures as previously described [20,21].
Temporary Middle Cerebral Artery Occlusion (tMCAO).
CSF was collected by cisternal puncture when the animals were killed at either 2 h [sham (n = 4), pMCAO (n = 5), tMCAO (n = 3)] or 24 h [sham (n = 5), pMCAO (n = 4), tMCAO (n= 3)] postsurgery.
To test how different delivery routes may impact the therapeutic effect of ADSC-E on stroke, we induced tMCAO on SD Rat.
The authors have shown that SCM-198 significantly decreased the volume of infarction and improved the neurologic deficit in the tMCAO model.
24 h after pMCAo Drug Infarct volume ([mm.sup.3]) Cortex Striatum Treatment Vehicle 69.43 [+ or -] 1.87 46.03 [+ or -] 2.7 Subchronic Chronic CGS21680 61.37 [+ or -] 8.26 45.68 [+ or -] 2.6 Subchronic 0.1 Chronic 0.1 Chronic 0.01 7 days after tMCAo Drug Infarct volume ([mm.sup.3]) Cortex Striatum Vehicle 75.1 [+ or -] 5.1 28.4 [+ or -] 2.2 76.2 [+ or -] 4.3 31.3 [+ or -] 2.6 CGS21680 62.7 [+ or -] 5.8 30.5 [+ or -] 2.5 48.6 [+ or -] 9.5 (#) 27.3 [+ or -] 1.7 51.9 [+ or -] 10.4 (#) 20.9 [+ or -] 3.8 Data are the mean [+ or /] S.E.M.
The STVNA dose-response relationship was investigated in the transient ischemia model (tMCAO).
In the excitatory or inhibitory stimulation experiments, animals were randomly divided into four groups that designed to receive (1) PBS (PBS group); (2) PBS followed by laser stimulation (PBS-E for excitation or PBS-I for inhibition groups, resp.); (3) NSC transplantation (NSC group); and (4) NSC transplantation followed by laser stimulation (NSC-E or NSC-I group, resp.) after 60-minute tMCAO surgery.
Permanent middle cerebral artery occlusion (pMCAO) and transient middle cerebral artery occlusion (tMCAO) followed by reperfusion are major experimental animal models used to investigate ischemic stroke .
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