Jones, "TMEM: a novel breast cancer dissemination marker for the assessment of metastatic risk," Biomarkers in Medicine, vol.
Cieslikowski et al., "Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors," BMC Cancer, vol.
The methods include the identification and measurement of the number of actual sites (called the TMEM
or MetaSite) where metastatic cancer cells enter the bloodstream.
Jones and Robinson developed a triple immunostain for human breast cancer samples that simultaneously labels the three cell types that together they named TMEM (Tumor Microenvironment of Metastasis).
They found that TMEM density was more than double in the group of patients who developed systemic metastases compared with the patients with only localized breast cancer (median of 105 vs.
The test, by scientists at the Albert Einstein College of Medicine at Yeshiva University, New York, discovered that for every 10-unit increase in TMEM
density, the risk of metastatic cancer doubled.
The research team has identified a marker called TMEM
, for Tumor Microenvironment of Metastasis, density of which is associated with the development of distant organ metastasis via the bloodstream - the most common cause of death from breast cancer.
A site with all three cells constitutes a "tumour micro-environment of metastasis" or TMEM
. The test detects the presence and density of TMEMs
in breast tissue biopsy samples.
Outro parametro significativo no estudo da manutenibilidade de um sistema e o Tempo Medio Entre Manutencao (TMEM
), que e o tempo de plena operacao do sistema, sem nenhuma falha.
In addition, Alan Jones has been named executive vice president of Toyota Motor Engineering & Manufacturing Europe (TMEM
) and chairman of Toyota Motor Manufacturing U.K.
To develop a network of TMEM
professionals, experts and institutions within the region as a support network for the continuous professional growth of the program s graduates
The findings showed that the MetaSite Score, a count of the number of tumour microenvironment of metastasis (TMEM
) structures, was related to a statistically significant rise in the risk of distant metastasis.