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By altering TMEV to contain bacterial proteins resembling myelin, this team showed how T cells responding to the virus would initiate, or exacerbate, MS-like disease.
A virus related to TMEV, named Vilyuisk virus, was isolated from a laboratory mouse that had been injected intracerebrally with blood and cerebrospinal fluid (CSF) of a symptomatic patient (11,12).
In this study, we used broad-range nested reverse transcription--PCR (RT-PCR) targeted at domains conserved between the Saffold prototype virus, various TMEV strains, and EMCV.
EF165067) (16) with genomes of EMCV and TMEV strains.
The following sequences were used for analysis and primer design: Saffold virus (EF 165067), TMEV strain DA (M20301), TMEV strain GDVII (M20562), TMEV strain BeAn (M16020), Vilyuisk virus (M94868), Theiler-like virus of rats NGS910 (AB090161), Mengo virus (L22089), and EMCV (X87335).
The 5'-noncoding region of this sequence was aligned with that of other cardioviruses, including TMEV, EMCV, and Mengo virus.
The molecular ecology of SaVf seems especially relevant in view of the diversified and strain-dependent pathogenetic changes caused by the related TMEV in rodents.
Theiler's murine encephalomyelitis virus-(TMEV-) induced demyelinating disease (TMEV-IDD), another popular model for MS, is induced by intracerebral injection with TMEV resulting in CNS inflammation .
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