TMPRSSTransmembrane Protease, Serine
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Proteolytic activation of seasonal human IAV HA occurs extracellularly or on the cell membrane in the airway by trypsin-type proteases, such as tryptase Clara, (19) mini-plasmin, (7) trypsin, (3) ectopic pancreatic trypsin, (4),(8),(10),(11),(21) porcine lung tryp tase, (22) TC30 (23) and type-II membrane bound proteases, human airway trypsin-like protease (HAT), transmembrane serine protease (TMPRSS)2 (24) and TMPRSS4 (25) (Table 1).
Also, research continues on TMPRSS:ERG gene fusions, found in the urine of some prostate cancer patients, to determine their value in detecting prostate cancer.