With this goal, we compared thigh magnetic resonance imaging (tMRI) in patients with IMNM and MADD to achieve a differential diagnosis between the two diseases.
Forward multiple logistic regression was used to select the tMRI features that were most informative for clinical data.
The tMRI revealed fatty infiltration in 22 patients and edema in 11 patients [Figure 2]a and [Figure 2]b.
The tMRI results showed various extents of fatty infiltration and edema among the thirty patients [Figure 2]c and [Figure 2]d.
These findings were similar to a previous report on muscle imaging changes in South Chinese patients with MADD. Interestingly, all our patients originated from northern region of China, suggesting that tMRI of MADD patients may not show regional differences.
The patients with IMNM had moderate or severe muscle fatty infiltration and edema in the posterior compartment by tMRI in our study.
Furthermore, muscle edema was strongly associated with IMNM in logistic regression models, also strengthening the hypothesis that muscle edema in tMRI would be an effective indicator to achieve a differential diagnosis between the two diseases.