TNFAIP3Tumor Necrosis Factor-Alpha-Induced Protein 3
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Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
B signaling pathway such as activating mutations of MYD88, CARD11 , and CD79 , and deletions of TNFAIP3 and TBL1XR1 , indicating that the activation of NF-?
Similarly, the expression of 18 cytokine genes (IL-7, IL-10, TNFAIP8, SPP2, TNFAIP3, IFNB, CCL19, TNFAIP8L1, IL-16, CNTF, CXCL13, TNFAIP8L3, TNFSF13B, IL-34, TGFB1, TNFAIP2, CCL3, and ADIPOQ) and 39 cytokine receptor genes (CXCR7, CSF2RA, IL-1RL1, I-L1R2, IL-17RA, IFNAR1, IL-18RAP, IL-31RA, IL-9R, IL-18R1, IL-20RB, IL-21R, IL-2RG, IL-20RA, IL-4I1, LILRB1, TLR1, IL-17REL, LILRB5, TGFBR1, TLR6, TNFRSF13B, XCR1, TLR7, TNFRSF13C, TLR15 etc.
64 Alpha-Induced Protein 2 TNFAIP3 Tumor Necrosis Factor, 2.
8 kb apart, but statistically independent, on 6q23 near TNFAIP3 (TNF alpha-induced protein 3) and OLIG3 (oligodendrocyte transcription factor 3), through a strategy of cross-comparison of their dataset with public datasets (55).
Comparison of Genetic Aberrations in Splenic Small B-Cell Lymphomas (a) Variable Gene Mutation Associated Structural Abnormality SMZL NOTCH2 (~25%) del 7q (~45%); Less NF-[kappa]B pathwa commonly: trisomy (BIRC3, TNFAIP3, 3, trisomy 12, MAP3K14, IKBKB) trisomy 18, 17p (~33%) (TP53) Rare: MYD88 L265P SDRPL Unknown Uncommon: del 7q, trisomy 18, del 17p (TP53) HCL-v MAP2K1 (~33%) del 17p (TP53) (~33%); Uncommon: 5q gain, del 7q HCL BRAF V600E (>90%) Rare: 5q gain, del 7q LPL MYD88 L265P (~90%) del 6q (~45%); Uncommon: del 13q, del 7q Abbreviations: HCL, hairy cell leukemia; HCL-v, hairy cell leukemia variant; LPL, lymphoplasmacytic lymphoma; NF-[kappa]B, nuclear factor-[kappa]B; SDRPL, splenic diffuse red pulp small B-cell lymphoma; SMZL, splenic marginal zone lymphoma.
sup][16],[17] Studies have also reported that mutations of genes such as v-rel avian reticuloendotheliosis viral oncogene homolog,[sup][18],[19] nuclear factor of kappa light polypeptide gene enhancer in B-cells 1,[sup][20],[21] and TNF-a induced protein 3 ( TNFAIP3 ),[sup][5] involved in the pathological NF-?
TNFAIP3 is the target gene of chromosomal band 6q23.
Cluster 1 genes (ZBTB1, PML, ZNF44, SIX1, BCL6, ZNF450) were down-regulated by V and involved in gene transcription, whereas cluster 2 genes (IL8, IL1A, PTGS2, DTR, TNFAIP3, CXCL3) were up-regulated and linked to inflammatory response and cell proliferation.