miRNA: micro-RNA RISC: RNA-induced silencing complex Ago2: Argonaut 2 TRBP: Human immunodeficiency virus transactivating response RNA-binding protein IL: Interleukins RANKL: Receptor activator of nuclear factor kappa-B ligand TLR: Toll-like receptors TNF-[alpha]: Tumor necrosis factor alpha MMP: Matrix metalloproteinases CCL2: Chemokine ligand 2 CDK2: Cyclin-dependent kinase 2 Cyr61: Cysteine-rich angiogenic inducer 61 TNFAIP3
: Tumor necrosis factor alpha-induced protein 3 BCL2: B cell lymphoma 2 M-CSF: Macrophage colony-stimulating factor IKK-[alpha]: Inhibitor of nuclear factor kappa-B kinase subunit alpha PADI4: Peptidylarginine deiminase 4 gene Tregs: Regulatory T cells PTPN22: Protein tyrosine phosphatase, nonreceptor type 22 gene.
Aguiar, "MicroRNAs miR-125a and miR-125b constitutively activate the NF-kappaB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3
, A20)," Proceedings of the National Academy of Sciences of the United States of America, vol.
The expression of 15 cytokines genes (ADIPOQ, BMP2K, CCL3, CXCL13, IL-16, IL-28B, IL-34, SPP1, TGFB1, TNFAIP2, TNFAIP3
, TNFAIP8, TNFAIP8L1, TNFSF11, and TNFSF13B) was significantly upregulated by 2.1- to 9.25-fold (Supplementary Table S4, Figure 4), while 46 cytokine receptors (CSF3R, CXCR7, IL-17RA, IL-18R1, IL-1R1, IL-1R2, IL-20RA, IL-21R, IL-2RG, IL-4I1, IL-5RA, IL-7R, IL-9R, LILRB3, TGFBR1, TLR1, TLR15, TLR21, TLR5, TLR6, TLR7, TNFRSF13B, TNFRSF13C, TNFRSF1B, TRAT1, XCR1, etc.) were also significantly upregulated by 2.04- to 10.16-fold in chicken line 6.3 with p < 0.01 and fold [greater than or equal to] 2 (Supplementary Table S4, Figure 5).