TNFAIP3Tumor Necrosis Factor-Alpha-Induced Protein 3
References in periodicals archive ?
(13, 14) A South Korean study by Jung et al (14) reported that TNFAIP3 was the most frequently mutated gene in ocular MZL followed by TBL1XR1 and CREBBP, and MYD88 mutation was identified in only 4% of patients.
TNFAIP3, also known as A20, is an ubiquitin-editing enzyme, which has dual roles in ubiquitin ligase and deubiquitinase activity.
miRNA: micro-RNA RISC: RNA-induced silencing complex Ago2: Argonaut 2 TRBP: Human immunodeficiency virus transactivating response RNA-binding protein IL: Interleukins RANKL: Receptor activator of nuclear factor kappa-B ligand TLR: Toll-like receptors TNF-[alpha]: Tumor necrosis factor alpha MMP: Matrix metalloproteinases CCL2: Chemokine ligand 2 CDK2: Cyclin-dependent kinase 2 Cyr61: Cysteine-rich angiogenic inducer 61 TNFAIP3: Tumor necrosis factor alpha-induced protein 3 BCL2: B cell lymphoma 2 M-CSF: Macrophage colony-stimulating factor IKK-[alpha]: Inhibitor of nuclear factor kappa-B kinase subunit alpha PADI4: Peptidylarginine deiminase 4 gene Tregs: Regulatory T cells PTPN22: Protein tyrosine phosphatase, nonreceptor type 22 gene.
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
Wu et al., "Functional effect of polymorphisms in the promoter of TNFAIP3 (A20) in acute pancreatitis in the Han Chinese population," PLoS One, vol.
Wang et al., "Polymorphisms of the TNFAIP3 region and Graves' disease," Autoimmunity, vol.
Fukao, "A Japanese family case with juvenile onset Behccet's disease caused by TNFAIP3 mutation," Allergology International, vol.
Aguiar, "MicroRNAs miR-125a and miR-125b constitutively activate the NF-kappaB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20)," Proceedings of the National Academy of Sciences of the United States of America, vol.
Expression, biological activities and mechanisms of action of A20 (TNFAIP3).
A genetic analysis of the cells lining the mice's lungs revealed that Tnfaip3, the gene for making the enzyme A20, had been switched on.
The expression of 15 cytokines genes (ADIPOQ, BMP2K, CCL3, CXCL13, IL-16, IL-28B, IL-34, SPP1, TGFB1, TNFAIP2, TNFAIP3, TNFAIP8, TNFAIP8L1, TNFSF11, and TNFSF13B) was significantly upregulated by 2.1- to 9.25-fold (Supplementary Table S4, Figure 4), while 46 cytokine receptors (CSF3R, CXCR7, IL-17RA, IL-18R1, IL-1R1, IL-1R2, IL-20RA, IL-21R, IL-2RG, IL-4I1, IL-5RA, IL-7R, IL-9R, LILRB3, TGFBR1, TLR1, TLR15, TLR21, TLR5, TLR6, TLR7, TNFRSF13B, TNFRSF13C, TNFRSF1B, TRAT1, XCR1, etc.) were also significantly upregulated by 2.04- to 10.16-fold in chicken line 6.3 with p < 0.01 and fold [greater than or equal to] 2 (Supplementary Table S4, Figure 5).