26) investigated TNF alpha, TNFR
and HAI values in 105 patients with chronic HCV and a control group of 48 healthy subjects.
OPG, tambien conocida como factor inhibidor de la osteoclastogenesis (OCIF), miembro TNFR
SF11B, actua como un receptor bloqueador de RANKL, provocando efectos opuestos a los de RANKL en el metabolismo oseo (Lacey y cols.
Death receptor 5-mediated TNFR
family signaling pathways modulate [gamma]-humulene-induced apoptosis in human colorectal cancer HT29 cells.
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR
Severe renal inflammation was observed in convalescent TNFR
NOX, NADPH oxidases; TNF-[alpha], tumor necrosis factor-a; EGF, epidermal growth factor; IL-1[beta], Interleukin-1[beta]; SOD, superoxide dismutase; GPx, glutathione peroxidase; GST-pi, glutathione S-transferase pi; MT3, metallothionein-3; FHC, ferritin heavy chain; DDH1, dihydrodiol dehydrogenase; TNFR
, tumor necrosis factor receptor; TRADD, TNFRSF1A-associated via death domain; MyD88, myeloid differentiation factor 88; TLR, Toll-like receptor; cPLA2, cytosolic phospholipases A2.
Abbreviations: ALP, alkaline phosphatase; BMSCs, bone marrow stromal cells; DKK-1, Dickkopf-1; DMEM, Dulbecco's modified eagle medium; ELISA, enzyme-linked immunosorbent assays; FBS, fetal bovine serum; MIT, methyl thiazolyl tetrazolium assay; OIM, osteogenic induction medium; OPG, osteoprotegerin; PNPP, p-nitrophenyl phosphate; PNS, Panax notoginseng saponins; PPAR-[gamma]2, peroxisome proliferator-activated receptor-[gamma]2; RANK, receptor activator of NF-KB; RANKL, receptor activator of NF-KB ligand; TNFR
family, tumor necrosis factor receptor family.
HCV antigens, in particular the core protein, play a key role in the pathogenesis of chronic HCV and hepatocarcinogenesis through the TNFR
, PKR, and STAT3 pathways .
6) Apoptosis can also be induced by pathways that depend on the activation of the cellular immune response through Fas/Fas-L and TNFR
, pathways that are involved in both tissue injuries and control mechanisms of the immune response.
Xu, "Soluble TNFR
II/IgG1 Fc fusion protein treatment in the LPS-mediated septic shock of rats," Biomedicine and Pharmacotherapy, vol.
inhibits the immune stimulating activity of TNF-alpha.
Local administration of a DNA sequence encoding a soluble TNFR
potentially may supplement currently used drugs in a number of inflammatory conditions.