TNFR:FcTumor Necrosis Factor Receptor:Fc Fusion Protein
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Data from preclinical studies conducted in an animal model of inflammatory arthritis demonstrated that a single injection of rAAV encoding a soluble form of the rat TNFR:Fc vector into the ankles of arthritic rats resulted in a significant reduction in ankle and hind paw swelling as measured by arthritis index scores.
In these studies, the rat TNFR:Fc gene, which was cloned by Targeted Genetics in 1998, was delivered using the Company's adeno-associated virus (AAV) vectors.