2010) Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1
Results also show that whereas soluble TNFR1
was independent of BCG dose, soluble TNFR2 was released in a BCG dose dependent manner.
Overall African American [rho] P value [rho] P value TNFR1
There was no correlation among TNF-[alpha], TNFR1
, and TNFR2 even when controlling for TR.
The loss of expression of TNFR1
explains TNF-[alpha] unresponsiveness, and resistance to TRAIL may be due to overexpression of the antiapoptotic protein c-FLIP and frequent loss of the proapoptotic protein BID.
O receptor TNFR1
e similar (APO-1/Fas) ao receptor CD95, que apresenta uma sequencia 80 aminoacidos, quando presente na regiao intracelular e referida como "dominio da morte", esta regiao e responsavel pela transmissao do sinal de inducao da citocina TNF-[alpha].
is expressed on OLGs, microglia, or astrocytes in culture [43-44] and may be important in demyelination in vivo.
levels on scene and at hospital admission were higher in more severely injured patients.
When cuprizone was stopped in mice lacking TNFR1
, myelin started to form again, indicating this receptor was not crucial to myelin repair.
Activation of TNFR1
ectodomain shedding by mitochondrial [Ca.
Mechanistic study revealed that the combination treatment increased the TNFR1
expression and decreased mitochondrial membrane potential in MDA-MB-435 and MDA-MB-231 cells (Yeruva et al.