Members of the TNF receptor super family (TNFRSF
) are attractive targets for developing functional antibodies since stimulating this class of receptors potently regulates a wide variety of biological functions.
Brink, "Regulation of TNFRSF
and innate immune signalling complexes by TRAFs and cIAPs," Cell Death and Differentiation, vol.
Osteoprotegerin (OPG) is a tumor necrosis factor receptor superfamily member (TNFRSF
) that exerts protective properties against OP.
DR3, also known as APO-3, TRAMP, LARD, and WSL-1, is a member of the tumor necrosis factor receptor superfamily (TNFRSF
) with a typical death domain that consists of an approximately 60-amino-acid globular bundle of 6 conserved [alpha] helices found in the cytoplasmic region.
During the later stage of T-cell activation, other costimulatory molecules which belong to the TNFRSF
such as CD137 and OX40 start to participate in the scene of costimulation.