The ratios of peak values, declines, and delayed peaks for the TNGT, TIGR, and TDM groups were 6.3%, 11.4%, and 55.9%, respectively, while the ratios for the NGT, IGR, and T2DM groups were 9.1%, 32.1%, and 80.0%, respectively.
The I[sub]p/I[sub]0, AIR[sub]0′~10′, and AUC[sub]ins-IVGTT values of the TDM group were higher than those of the T2DM group but were lower than those of the TNGT, TIGR, NGT, and IGR groups.
Moreover, the HOMA-[sz] values of the TNGT and TDM groups were higher than those of the NGT and T2DM groups.
However, in the hyperthyroidism groups, despite the lower MBCI in the TIGR group compared with the TNGT group, the difference was not statistically significant, indicating no difference in [sz]-cell function between these groups.
In the OGTT, although the I[sub]p/I[sub]0 values of the TNGT and TDM groups were higher than those of the NGT and T2DM groups, the AUC[sub]ins-OGTT and AUC[sub]ins-OGTT/AUC[sub]glu-OGTT values of the TIGR and TDM groups were higher than those of the IGR and T2DM groups, although the differences were not statistically significant.
The I[sub]P values of the hyperthyroidism groups (TNGT, TIGR, and TDM) were significantly higher than those of the NGT, IGR, and T2DM groups, indicating that all but the T2DM group retained normal first-phase insulin secretion.